Effects of penicillinase on bactericidal and complement activities in normal human serum

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Effects of penicillinase on bactericidal and complement activities in normal human serum.

During routine addition of penicillinase (beta-lactamase) to patients sera, we found that the capacity of some of these sera to kill serum-sensitive gram-negative organisms was significantly decreased. Further controlled studies showed that penicillinase decreased both the bactericidal activity of normal human sera and the total hemolytic activity (CH50) of complement in these sera. The decreas...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1983

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.23.5.738